2024 ACCP Journal of Clinical Pharmacology Journal CE | October 2024

This activity increases knowledge around the consideration of age-related maturation of drug metabolizing enzymes as a factor that can be used in physiologically-based pharmacokinetic (PK) modeling to predict pediatric PK. Enhanced understanding of ontology functions of drug metabolizing enzymes such as the cytochrome P450 family and UDP-Glucuronosyltransferase (UGTs) is essential to accurately predicting PKs in pediatric patients and potentially limiting adverse drug effects. Learners that complete this activity will have an increased understanding of the age-dependent expression of various UGT enzymes. Participants will have the opportunity to compare the ontogeny functions for eight select UGTs based on a meta-analysis of both published in vitro and in vivo studies meeting the inclusion criteria. Completing this activity will provide an increased understanding of PK modeling incorporating ontogeny functions in UGTs to more accurately predict pediatric PK for drugs that are susceptible to glucuronidation.

Credit & MOC Details

Credit information is provided by the course provider. We recommend confirming credit eligibility with the provider or your licensing board before starting the activity.

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Journal-based
Credit · Up to 1 credit
Fee · varies

Released

Oct 1, 2024
Last day to claim credit

Oct 2, 2027 12 months left

2024 ACCP Journal of Clinical Pharmacology Journal CE | October 2024

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