Profound lactic acidosis and refractory hypoglycemia are rare but critical indicators of underlying malignancy. We report a case of diffuse large B-cell lymphoma presenting with the aforementioned metabolic derangements consistent with the Warburg effect and its extreme form, hyper-Warburgism. This phenomenon reflects aggressive tumor metabolism driven by aerobic glycolysis leading to excess lactate and glucose consumption. A comprehensive workup excluded infectious, ischemic, and metabolic causes, and the diagnosis was eventually confirmed via biopsy. Despite treatment, the disease rapidly progressed, leading to multiorgan failure. This case emphasizes the importance of recognizing atypical metabolic presentations as signs of aggressive malignancy because early identification of hyper-Warburgism can expedite oncologic evaluation, guide management, and potentially improve outcomes.
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- Journal-based
- Credit · Up to 1 credit
- MOC · Up to 1 point
- Fee varies · this provider typically $25
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ReleasedJul 1, 2026
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Last day to claim creditJul 2, 2027 9 months left
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Cincinnati Children’s Hospital Medical Center Online Child Psychiatry Grand Rounds 2025: Hyper-Extralemniscal Thalamic Hypothesis of Fragile X Syndrome 8.13.2025
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American College of Endocrinology 2026 Rare Diseases Webinar Series -Improving Recognition, Diagnosis, and Management of Post-Bariatric Hypoglycemia
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Binaytara Oncoblast-Updates in Management of Diffuse Large B-Cell Lymphoma
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A. Webb Roberts Center for Continuing Medical Education of Baylor Scott & White Health 2026 Clinician Corner – Acute-onset autoimmune type 1 diabetes presenting with diabetic ketoacidosis in an obese adult
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A. Webb Roberts Center for Continuing Medical Education of Baylor Scott & White Health 2026 Clinician Corner – Bullous pemphigoid preceding the diagnosis of colorectal adenocarcinoma
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A. Webb Roberts Center for Continuing Medical Education of Baylor Scott & White Health 2026 Clinician Corner – Neurogenic shock to the heart: a rare case of meningitis-triggered reverse takotsubo cardiomyopathy
