This video presents the mechanism of action of the NO and the factors that trigger its release. STUDY NOTES: AUTOREGULATION – NITRIC OXIDE Nitric Oxide is called an endothelium derived relaxing factor(EDRF) as it is released by the endothelium of the blood vessel. EDRF cause relaxation of the vascular smooth muscle, and as a result cause vasodilation of the blood vessel. The following factors contribute to the release of nitric oxide from the endothelium: 1) Blood travelling at high velocity causes a shearing effect on the wall of the blood vessels. As the endothelial cells endure a drag force produced due to friction. This results in a mechanical trigger which stimulates release of nitric oxide. 2) Vasoactive Amines are chemical mediators that mediate the release of nitric oxide. 3) The endothelium possesses Histamine H1 receptors that also take part in nitric oxide release. 4) Prostacyclins are also said to be responsible for the release of nitric oxide.
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ReleasedNov 18, 2025
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Last day to claim creditNov 18, 2028 2 years left
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