Clyde Warren Yancy, MD
Vice Dean for Health Equity, Northwestern University Feinberg School of Medicine
Advanced Heart Failure & Transplant Cardiology
In this online, self-learning activity: Alpha-mannosidosis (AM) is a rare recessive lysosomal storage disorder characterized by immune deficiency, facial and skeletal abnormalities, hearing impairment, and intellectual disability. It is caused by mutations in the MAN2B1 gene, leading to deficiency in alpha-mannosidase, a lysosomal enzyme involved in the oligosaccharide degradation pathway. While the exact prevalence of AM in the US is unknown, it has an estimated incidence of 1 in 500,000 live births worldwide. Laboratory indicators of AM often appear shortly after birth, followed by progression of clinical manifestations. While symptoms of AM vary considerably in individual presentations, three clinical subtypes have been identified (mild, moderate, and severe) and are used to guide disease prognosis and management. The current diagnostic algorithm for AM focuses on measuring alpha-mannosidase activity in leukocytes using colorimetry or fluorimetry. An alpha-mannosidase activity level of under 5% suggests AM, and a diagnosis is then confirmed with genetic sequencing.
Credit & MOC Details
Credit information is provided by the course provider. We recommend confirming credit eligibility with the provider or your licensing board before starting the activity.
Credit types
AMA PRA Category 1 Credit™Up to 1 credit
MOC types
ABIM — Medical KnowledgeUp to 1 pointABP — Lifelong Learning and Self-AssessmentUp to 1 point
FDA REMS
No
Qualifies for MIPS
No
Target Specialties
Address:
- 1935 8th Avenue
Pricing
100% of listed courses are free
52 of 52 courses listed here are free.
Collected from the provider’s public pages · source
Specialties served/covered
- Adolescent Medicine
- Cardiovascular Disease
- Endocrinology, Diabetes & Metabolism
- Gastroenterology
- General Internal Medicine
- General Pediatrics
- Hematology
- Medical Oncology
- Neonatal-Perinatal Medicine
- Nephrology
- Neurocritical Care
- Neurology
- Ophthalmology
- Pediatric Gastroenterology
- Pediatric Hematology-Oncology
- Pediatric Infectious Diseases
- Pediatric Neurology
- Pediatric Radiology
- Pediatric Transplant Hepatology
- Pulmonary Disease
- Rheumatology
- Transplant Hepatology
- Cardio-Vascular
- Cross-Specialty
- Emergency & Critical Care
- GI & Liver
- Infectious Disease
- Internal Medicine
- Medical Subspecialties
- Neurology
- Oncology & Hematology
- Pediatrics
- Primary care
- Radiology
- Surgery
- No reviews yet. Be the first to share yours.
Faculty 1
All faculty
Pricing
Free
Reported to ACCME by the provider
- On-demand / recorded video
- Credit · Up to 1 credit
- MOC · Up to 1 point
- Commercial Support
-
ReleasedJan 6, 2025
-
Last day to claim creditJan 7, 2027 3 months left
-
ScientiaCME Alagille syndrome: best practices in its recognition and a review of present and novel approaches to management
-
ScientiaCME Early detection, lifetime protection: ADA-SCID identification and management, from cradle to adulthood
-
ScientiaCME The gMG care continuum: timely recognition, steroid-sparing strategy, and targeted therapy integration in generalized myasthenia gravis
