Self Tolerance and Microbe Triggered Autoimmunity (T Cell Focus) We have been discussing the autoantibodies or anti-idiotype antibodies for a few days. A frequent question asked is "How does the immune system start attacking our own tissues while it was not doing so before the COVID infection, or a Spike protein vaccine?" Let's build our understanding of these mechanisms. Page 350. Anergy and the role of tissue resident dendritic cells. Page 350. B cell tolerance. A beautiful mechanism of B cell receptor editing. Page 351. B cell deletion by an unknown mechanism. Normal mechanism is B cell anergy in the presence of abundant antigen from all sides of the immature B cell. Immunologic tolerance is defined as unresponsiveness to an antigen that is induced by exposure to that antigen. The term arose from the experimental observation that animals that had encountered an antigen under particular conditions would not respond to, that is, would tolerate, subsequent exposures to the same antigen. Abbas, Abul K.; Lichtman, Andrew H.; Pillai, Shiv. Cellular and Molecular Immunology E-Book (p. 337). Elsevier Health Sciences. Kindle Edition. Disclaimer: This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
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ReleasedNov 18, 2025
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Last day to claim creditNov 18, 2028 2 years left
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National Institute for the Clinical Application of Behavioral Medicine Expert Strategies to Help Clients Develop Tolerance for Emotional Distress
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Medscape, LLC The Challenge of Refractory HSV in Immunocompromised Patients: Testing, Toxicity, and Treatment Tolerance
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Cincinnati Children’s Hospital Medical Center Online Neonatology Grand Rounds 2024 – Mechanisms of Placental Tolerance and Immunity in Humans 11.1.2024
