In this online, self-learning activity: Actinic keratosis (AK) is a disorder characterized by precancerous epidermal lesions caused by cumulative sun exposure that may progress to squamous cell carcinoma. It is one of the most common dermatologic diagnosis in U.S. patients, and its prevalence is increasing, with three in ten Medicare patients having a AK-related healthcare visit. AK develops due to excessive radiation exposure from the sun inducing pathologic changes in the epidermal keratinocyte through the disruption of regulatory pathways involved in cell growth and differentiation. Inflammation and immunosuppression lead to the intraepidermal generation of abnormal keratinocytes, which give rise to AKs. Generally, AKs are asymptomatic but some patients may experience local tenderness in addition to the multitude of clinical variants seen upon presentation. The average risk for malignant transformation is 8% in immunocompetent patients, with a range from 0.025% to 16%. However, while the risk of malignant transformation is relatively low, the majority of squamous cell carcinomas stem from AKs.
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- Adolescent Medicine
- Cardiovascular Disease
- Endocrinology, Diabetes & Metabolism
- Gastroenterology
- General Internal Medicine
- General Pediatrics
- Hematology
- Medical Oncology
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ReleasedApr 28, 2024
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Last day to claim creditApr 29, 2027 7 months left
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ScientiaCME Recognition and management of epidermolysis bullosa: what the clinician needs to know
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