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StatPearls, LLC

  • Acetaminophen
  • Acute Kidney Injury
  • Analgesics
  • Drug Overdose
  • Poisoning

Acetaminophen Toxicity

Acetaminophen is one of the most commonly used analgesics and antipyretics. Although generally safe at therapeutic doses, acetaminophen poisoning causes hepatic necrosis in overdose. Acetaminophen toxicity is the second most common reason for liver transplantation worldwide and the most common cause of acute liver failure in the United States. Responsible for 56,000 emergency department visits and 2600 hospitalizations, acetaminophen poisoning causes 500 deaths annually in the United States. Approximately 50% of these poisonings are unintentional, often resulting from patients misinterpreting dosing instructions or unknowingly consuming multiple acetaminophen-containing products. The mortality associated with acetaminophen overdose is low if recognized and treated within the first 8 hours after an acute ingestion. Factors such as alcohol use, genetics, age, medications, use of herbal supplements, and nutritional status may affect the prognosis. While hepatic injury is the most common effect of acetaminophen poisoning, acute renal injury is also common. This activity reviews the etiology, evaluation, treatment, and management of acetaminophen poisoning while highlighting the use of interprofessional teams to manage and prevent this problem.

Credit & MOC Details

Credit information is provided by the course provider. We recommend confirming credit eligibility with the provider or your licensing board before starting the activity.

Credit types

IPCE CreditsUp to 2 creditsAAPA Category 1 Credit™Up to 2 creditsAMA PRA Category 1 Credit™Up to 2 creditsNursingUp to 2 creditsPharmacyUp to 2 credits

MOC types

ABS — Accredited CMEUp to 2 pointsABPM — Accredited CMEUp to 2 pointsABPATH — Lifelong LearningUp to 2 pointsABA — Lifelong LearningUp to 2 pointsABTS — Accredited CMEUp to 2 pointsABIM — Medical KnowledgeUp to 2 pointsABS — Self-AssessmentUp to 2 pointsABP — Lifelong Learning and Self-AssessmentUp to 2 pointsABPM — Self-AssessmentUp to 2 pointsABTS — Self-AssessmentUp to 2 points

FDA REMS

No

Qualifies for MIPS

No

Target Specialties

Cross-Specialty

Relevant across 9 specialties.

Pricing

Fee varies

This provider typically $49–98

See fees on statpearls.com

Listed by the provider

  • Article / monograph / reference
  • Credit · Up to 2 credits
  • MOC · Up to 2 points
  • Fee varies · this provider typically $49–98
  • Released
    Sep 1, 2026
  • Last day to claim credit
    Sep 1, 2029 3 years left

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