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StatPearls, LLC

  • Antifungal Agents
  • Ergosterol
  • Fluconazole
  • Itraconazole
  • Miconazole

Antifungal Ergosterol Synthesis Inhibitors

This activity delves into the pharmacological intricacies of antifungal ergosterol synthesis inhibitors, commonly called “azoles.” These medications, encompassing miconazole, ketoconazole, fluconazole, itraconazole, voriconazole, posaconazole, isavuconazole, and oteseconazole, play a crucial role in managing diverse fungal infections. The primary mechanism of action involves the inhibition of ergosterol biosynthesis, leading to the disruption of fungal cell membrane integrity. Exploring these azole antifungal agents involves covering indications, contraindications, drug interactions, and adverse event profiles. Notably, the potential for hepatotoxicity necessitates vigilant monitoring and interprofessional communication. These agents’ scientific and medical examination includes in-depth discussions on pharmacokinetics, monitoring protocols, clinical toxicology, and elucidating significant box warnings. By imparting insights into absorption, distribution, metabolism, and elimination, healthcare professionals will be equipped to make informed decisions, ensuring optimal patient outcomes. The emphasis on adverse drug reactions, such as QT interval prolongation and hepatotoxicity, along with a thorough exploration of contraindications, empowers clinicians with the knowledge essential for safe prescribing practices, ultimately enhancing collaborative patient care.

Credit & MOC Details

Credit information is provided by the course provider. We recommend confirming credit eligibility with the provider or your licensing board before starting the activity.

Credit types

AAPA Category 1 Credit™Up to 1.5 creditsAMA PRA Category 1 Credit™Up to 1.5 creditsNursingUp to 1.5 creditsPharmacyUp to 1.5 credits

MOC types

ABS — Accredited CMEUp to 1.5 pointsABPATH — Lifelong LearningUp to 1.5 pointsABA — Lifelong LearningUp to 1.5 pointsABTS — Accredited CMEUp to 1.5 pointsABIM — Medical KnowledgeUp to 1.5 pointsABS — Self-AssessmentUp to 1.5 pointsABP — Lifelong Learning and Self-AssessmentUp to 1.5 pointsABOHNS — Self-AssessmentUp to 1.5 pointsABTS — Self-AssessmentUp to 1.5 points

FDA REMS

No

Qualifies for MIPS

No

Target Specialties

Cross-Specialty

Relevant across 10 specialties.

Pricing

Fee varies

This provider typically $49–98

See fees on statpearls.com

Listed by the provider

  • Article / monograph / reference
  • Credit · Up to 1.5 credits
  • MOC · Up to 1.5 points
  • Fee varies · this provider typically $49–98
  • Released
    Sep 1, 2026
  • Last day to claim credit
    Sep 1, 2029 3 years left

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