Anemia, Pernicious
Gastritis, Atrophic
Helicobacter Infections
Vitamin B 12
Vitamins

Cyanocobalamin

Cyanocobalamin is a synthetic compound of vitamin B12 used to treat vitamin deficiencies. Chemically, cyanocobalamin is classified as a “corrinoid,” representing a crystallizable cobalt complex. The name “cyanocobalamin” is derived from including a cyanide group within the molecule. Cyanocobalamin is approved by the United States Food and Drug Administration (FDA) for pernicious anemia, malabsorption, atrophic gastritis, gastrectomy, Helicobacter pylori infection, and other conditions. Vitamin B12 facilitates several methylation reactions within the body. Methylcobalamin serves as a cofactor in the conversion of homocysteine to methionine in the body. Furthermore, in the form of adenosylcobalamin, the vitamin is crucial in converting methylmalonyl-coenzyme A (CoA) to succinyl-CoA. Both of these reactions are essential for cell division and growth. This activity provides a comprehensive review of cyanocobalamin, covering the indications, mechanism of action, adverse event profile, contraindications, and relevant interactions, as a valuable agent managing vitamin B12 deficiencies. This review is particularly relevant for interprofessional healthcare teams who care for patients with indicated conditions to enhance long-term outcomes.

Credit & MOC Details

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