Antitussive Agents
Cough
Dextromethorphan
Drug Overdose
N-Methylaspartate

Dextromethorphan

Dextromethorphan is a centrally acting, nonopioid antitussive widely used for cough suppression and increasingly recognized for its therapeutic potential in neuropsychiatric care. Commonly found in over-the-counter cough and cold products, it has multiple central nervous system effects, including N-methyl-D-aspartate receptor antagonism and sigma-1 receptor agonism. These properties support its FDA-approved use for pseudobulbar affect when combined with quinidine and for major depressive disorder when combined with bupropion, highlighting the importance of understanding its mechanisms and clinical applications. This activity provides a focused review of dextromethorphan, covering pharmacology, pharmacokinetics, therapeutic indications, and key safety considerations. The activity also reviews factors affecting metabolism, including cytochrome P450 2D6 variability, clinically relevant drug interactions, and the risk of serotonin syndrome, offering guidance for safe and effective clinical use. Additionally, recognition and management of misuse and overdose are addressed, including common clinical presentations and recommended interventions. By examining these aspects, healthcare professionals are equipped with the knowledge needed to optimize patient care and ensure the responsible use of dextromethorphan in both cough management and emerging neuropsychiatric therapies.

Credit & MOC Details

Credit information is provided by the course provider. We recommend confirming credit eligibility with the provider or your licensing board before starting the activity.