StatPearls, LLC

  • Cigarette Smoking
  • Diabetes Insipidus
  • Eosinophilic Granuloma

Eosinophilic Granuloma

An eosinophilic granuloma is an inflammatory myeloid neoplasm that is the mildest form of Langerhans cell histiocytosis, a rare group of disorders characterized by the abnormal proliferation of Langerhans cells, which are specialized immune cells originating from myeloid dendritic precursors. Eosinophilic granulomas primarily affect the axial skeleton, including the skull, jaw, spine, ribs, and pelvis. This neoplasm presents differently in children and adults. In children, skull lesions are the most common, while adults more frequently experience jaw involvement. The condition can manifest as a solitary lesion, which often requires minimal treatment, or as a multisystem disorder that demands aggressive therapies. Symptoms depend on the affected site and may include localized pain, swelling, fractures, and systemic issues such as diabetes insipidus or hearing loss. Pulmonary involvement is strongly associated with cigarette smoking. Diagnosis involves imaging studies, biopsy, and laboratory tests to confirm the presence of abnormal Langerhans cells. Treatment strategies vary based on disease severity, from observation to surgical interventions. This activity for healthcare professionals is designed to enhance the learner’s competence in recognizing the clinical features of eosinophilic granulomas, performing the recommended evaluation, and implementing an appropriate interprofessional management approach to improve patient outcomes.

Credit & MOC Details

Credit information is provided by the course provider. We recommend confirming credit eligibility with the provider or your licensing board before starting the activity.

Credit types

IPCE CreditsUp to 1.5 creditsAAPA Category 1 Credit™Up to 1.5 creditsAMA PRA Category 1 Credit™Up to 1.5 creditsNursingUp to 1.5 creditsPharmacyUp to 1.5 credits

MOC types

ABS — Accredited CMEUp to 1.5 pointsABOS — Accredited CMEUp to 1.5 pointsABPATH — Lifelong LearningUp to 1.5 pointsABTS — Accredited CMEUp to 1.5 pointsABIM — Medical KnowledgeUp to 1.5 pointsABS — Self-AssessmentUp to 1.5 pointsABP — Lifelong Learning and Self-AssessmentUp to 1.5 pointsABOHNS — Self-AssessmentUp to 1.5 pointsABTS — Self-AssessmentUp to 1.5 points

FDA REMS

No

Qualifies for MIPS

No

Target Specialties

Cross-Specialty

Relevant across 9 specialties.

Pricing

Fee varies

This provider typically $49–98

See fees on statpearls.com

Listed by the provider

  • Article / monograph / reference
  • Credit · Up to 1.5 credits
  • MOC · Up to 1.5 points
  • Fee varies · this provider typically $49–98
  • Released
    Sep 1, 2026
  • Last day to claim credit
    Sep 1, 2029 3 years left