Ependymoma
Molecular Diagnostic Techniques
Radiotherapy, Adjuvant

Ependymoma

Ependymomas are glial neoplasms originating from ependymal cells that line the cerebral ventricles and the central canal of the spinal cord. Representing approximately 2% to 3% of adult primary central nervous system tumors and up to 10% of pediatric brain tumors, ependymomas exhibit diverse anatomical and molecular profiles. Pediatric cases typically develop in the posterior fossa, whereas adult lesions more frequently are located within the spinal cord. The 2021 World Health Organization classification introduced molecular subgroups that refine the prognostic assessment and guide management decisions. Diagnosis integrates neuroimaging, histopathologic analysis, and molecular testing to distinguish tumor subtypes. Standard management involves maximal safe resection, often followed by adjuvant radiotherapy, while chemotherapy remains reserved for specific cases. Long-term surveillance is essential due to the risks of recurrence and treatment-related morbidity, highlighting the need for a coordinated multidisciplinary team follow-up approach. Through participation in this educational activity, clinicians will improve their ability to recognize ependymoma subtypes, interpret molecular and imaging findings, and integrate evidence-based strategies for diagnosis and management. This course enhances clinician competence in surgical planning, radiotherapeutic decision-making, and risk-adapted postoperative surveillance. Emphasis on interprofessional collaboration among neurosurgeons, neuro-oncologists, pathologists, radiation oncologists, radiologists, and rehabilitation medicine specialists promotes comprehensive, patient-centered care. By fostering communication across disciplines, clinicians improve diagnostic precision, reduce treatment variability, and support long-term functional and neurocognitive recovery in individuals affected by ependymoma.

Credit & MOC Details

Credit information is provided by the course provider. We recommend confirming credit eligibility with the provider or your licensing board before starting the activity.