Hypogammaglobulinemia is a disorder caused by low serum immunoglobulin or antibody levels. Immunoglobulins are the main components of the humoral immune response and able to recognize antigens to trigger a biological response and eradicate the infectious source. Hypogammaglobulinemia is the most common primary immunodeficiency and encompasses a majority of immune-compromised patients. In order to avoid the high morbidity and mortality associated with this condition, it must be promptly diagnosed and treated. The evaluation consists of lab tests, clinical findings, vaccination response, and genetic testing. Treatment is IVIG transfusions, antibiotics, and glucocorticoids. This activity highlights the role of the practitioner or interprofessional team to appropriately assess, evaluate, manage, and treat patients with this condition.
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Qualifies for MIPS
Target Specialties
Relevant across 10 specialties.
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- Addiction Medicine
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- Anatomic & Clinical Pathology
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- Medical Leadership & Administration
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- Article / monograph / reference
- Credit · Up to 2 credits
- MOC · Up to 2 points
- Fee varies · this provider typically $49–98
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ReleasedSep 1, 2026
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Last day to claim creditSep 1, 2029 3 years left
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Immunoglobulin National Society (IgNS) Beyond Primary: The Complexities of Secondary Immunodeficiencies
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American Academy of Otolaryngology – Head & Neck Surgery Foundation Evaluation and Treatment of Primary Immunoglobulin Deficiency Disorders in Chronic Rhinosinusitis (2025 AMW)
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A. Webb Roberts Center for Continuing Medical Education of Baylor Scott & White Health 2026 Clinician Corner – A rare case of TCF3-related agammaglobulinemia in a child with recurrent Haemophilus influenzae bacteremia
