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StatPearls, LLC

  • Anemia, Megaloblastic
  • Hyperuricemia
  • Lesch-Nyhan Syndrome
  • Nephrolithiasis
  • Uric Acid

Lesch-Nyhan Syndrome

This continuing medical education activity reviews the diagnosis and management of Lesch-Nyhan syndrome, an X-linked disorder of purine metabolism caused by hypoxanthine-guanine phosphoribosyltransferase deficiency. The condition is clinically significant because affected patients may develop hyperuricemia from birth, nephrolithiasis, dystonia, developmental delay, self-injurious behavior, megaloblastic anemia, and respiratory complications that contribute to reduced life expectancy. The practice gap addressed in this activity is delayed recognition and inconsistent interdisciplinary treatment, particularly when early neurological findings are misattributed to cerebral palsy, or hyperuricemia is treated without coordinated behavioral, dental, neurological, and renal prevention strategies. This activity addresses that gap by reviewing key biochemical, enzymatic, molecular, and clinical findings and outlining evidence-informed supportive care. Participants are expected to improve diagnostic accuracy, select appropriate urate-lowering and symptomatic therapies, prevent renal and tissue complications, and strengthen interprofessional care planning.

Credit & MOC Details

Credit information is provided by the course provider. We recommend confirming credit eligibility with the provider or your licensing board before starting the activity.

Credit types

AAPA Category 1 Credit™Up to 1.5 creditsAMA PRA Category 1 Credit™Up to 1.5 creditsNursingUp to 1.5 creditsPharmacyUp to 1.5 credits

MOC types

ABS — Accredited CMEUp to 1.5 pointsABOS — Accredited CMEUp to 1.5 pointsABPATH — Lifelong LearningUp to 1.5 pointsABA — Lifelong LearningUp to 1.5 pointsABTS — Accredited CMEUp to 1.5 pointsABIM — Medical KnowledgeUp to 1.5 pointsABS — Self-AssessmentUp to 1.5 pointsABP — Lifelong Learning and Self-AssessmentUp to 1.5 pointsABTS — Self-AssessmentUp to 1.5 points

FDA REMS

No

Qualifies for MIPS

No

Target Specialties

Cross-Specialty

Relevant across 11 specialties.

Pricing

Fee varies

This provider typically $49–98

See fees on statpearls.com

Listed by the provider

  • Article / monograph / reference
  • Credit · Up to 1.5 credits
  • MOC · Up to 1.5 points
  • Fee varies · this provider typically $49–98
  • Released
    Sep 1, 2026
  • Last day to claim credit
    Sep 1, 2029 3 years left

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