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StatPearls, LLC

  • Aldosterone
  • Epithelial Sodium Channel Blockers
  • Hypertension
  • Liddle Syndrome
  • Renal Insufficiency, Chronic

Liddle Syndrome (Pseudohyperaldosteronism)

Liddle syndrome, also known as pseudohyperaldosteronism, is a rare hereditary cause of early-onset, resistant hypertension resulting from a gain-of-function mutation in the epithelial sodium channel of the distal nephron. This mutation promotes excessive sodium reabsorption and potassium excretion, leading to hypertension, hypokalemia, and metabolic alkalosis. The syndrome follows an autosomal dominant inheritance pattern characterized by low plasma renin and aldosterone levels, distinguishing it from other mineralocorticoid excess states. Phenotypic variability and incomplete penetrance can obscure recognition, often resulting in delayed diagnosis or misclassification as essential hypertension or primary hyperaldosteronism. Without timely intervention, patients face increased risks of cardiovascular and renal complications, including heart failure, stroke, and chronic kidney disease. Early identification and targeted treatment with epithelial sodium channel inhibitors such as amiloride or triamterene are essential for controlling blood pressure and preventing disease progression. Through participation in this activity, clinicians strengthen their ability to identify, diagnose, and manage Liddle syndrome by integrating clinical findings, biochemical profiles, and genetic testing. Learners gain practical insight into differentiating this condition from other causes of pseudohyperaldosteronism and selecting appropriate pharmacologic therapies. The course emphasizes interprofessional collaboration among primary care clinicians, nephrologists, endocrinologists, genetic counselors, and pharmacists to enhance diagnostic accuracy, optimize therapeutic management, and ensure ongoing monitoring. Coordinated communication within the care team supports timely intervention, patient education, and long-term disease control.

Credit & MOC Details

Credit information is provided by the course provider. We recommend confirming credit eligibility with the provider or your licensing board before starting the activity.

Credit types

AAPA Category 1 Credit™Up to 1 creditAMA PRA Category 1 Credit™Up to 1 creditNursingUp to 1 creditPharmacyUp to 1 credit

MOC types

ABS — Accredited CMEUp to 1 pointABPATH — Lifelong LearningUp to 1 pointABA — Lifelong LearningUp to 1 pointABTS — Accredited CMEUp to 1 pointABIM — Medical KnowledgeUp to 1 pointABS — Self-AssessmentUp to 1 pointABP — Lifelong Learning and Self-AssessmentUp to 1 pointABTS — Self-AssessmentUp to 1 point

FDA REMS

No

Qualifies for MIPS

No

Target Specialties

Cross-Specialty

Relevant across 10 specialties.

Pricing

Fee varies

This provider typically $49–98

See fees on statpearls.com

Listed by the provider

  • Article / monograph / reference
  • Credit · Up to 1 credit
  • MOC · Up to 1 point
  • Fee varies · this provider typically $49–98
  • Released
    Sep 1, 2026
  • Last day to claim credit
    Sep 1, 2029 3 years left

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