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StatPearls, LLC

  • Erythema Nodosum
  • Lymphadenopathy
  • Sarcoidosis

Lofgren Syndrome

Löfgren syndrome is an acute, clinically distinct form of sarcoidosis characterized by the classic triad of erythema nodosum, bilateral hilar lymphadenopathy, and periarticular ankle inflammation. Occurring in approximately 5% to 10% of sarcoidosis cases, it typically affects younger adults and has high diagnostic specificity, often allowing diagnosis without tissue biopsy. The condition reflects an antigen-driven immune response in genetically susceptible individuals, with strong associations to HLA-DRB1*03 and a favorable prognosis, as most cases resolve spontaneously. This activity reviews the clinical and radiographic features, immunopathogenesis, and genetic influences of Löfgren syndrome, as well as differentiation from other granulomatous diseases. It emphasizes evidence-based evaluation and management, including appropriate use of imaging, laboratory testing, and selective pharmacologic therapy, while highlighting the importance of an interprofessional approach to optimize patient outcomes.

Credit & MOC Details

Credit information is provided by the course provider. We recommend confirming credit eligibility with the provider or your licensing board before starting the activity.

Credit types

AAPA Category 1 Credit™Up to 1.5 creditsAMA PRA Category 1 Credit™Up to 1.5 creditsNursingUp to 1.5 creditsPharmacyUp to 1.5 credits

MOC types

ABS — Accredited CMEUp to 1.5 pointsABPATH — Lifelong LearningUp to 1.5 pointsABA — Lifelong LearningUp to 1.5 pointsABTS — Accredited CMEUp to 1.5 pointsABIM — Medical KnowledgeUp to 1.5 pointsABS — Self-AssessmentUp to 1.5 pointsABTS — Self-AssessmentUp to 1.5 points

FDA REMS

No

Qualifies for MIPS

No

Target Specialties

Cross-Specialty

Relevant across 10 specialties.

Pricing

Fee varies

This provider typically $49–98

See fees on statpearls.com

Listed by the provider

  • Article / monograph / reference
  • Credit · Up to 1.5 credits
  • MOC · Up to 1.5 points
  • Fee varies · this provider typically $49–98
  • Released
    Sep 1, 2026
  • Last day to claim credit
    Sep 1, 2029 3 years left

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