This expert commentary reviews key clinical advances presented at the 2026 ASCO Annual Meeting that may influence the management of nonsmallcell and small cell lung cancers Faculty discuss the findings from LIBRETTO432 WUKONG28 HAROMNi6 CROWN and FLAME trials and IMforte and DELLphi304 posthoc analyses Readers will examine the phase III findings such as ivonescimab a bispecific antibody targeting PD1 and VEGF in advanced NSCLC and a variety of kinase inhibitors like selpercatinib for RET fusionpositive NSCLC sunvozertinib for EGFR exon 20 insertion NSCLC a 7year followup of lorlatinib for ALKpositive NSCLC and a phase II treatment escalation study of osimertinib plus chemotherapy for persistent EGFRmutated NSCLC Readers will also find new clinical data on FDAapproved therapies through several post hoc analyses such as the intracranial efficacy of tarlatamab in extensivestage SCLC and transcriptomic and qualityoflife analyses of maintenance lurbinectedin plus atezolizumab in extensivestage SCLC
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