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StatPearls, LLC

  • Anti-Bacterial Agents
  • Doxycycline
  • Erythromycin
  • Lymphogranuloma Venereum
  • Proctocolitis

Lymphogranuloma Venereum Infection

Lymphogranuloma venereum is a sexually transmitted infection (STI) caused by Chlamydia trachomatis, specifically the L1, L2, and L3 serovars, which differ from those responsible for more common Chlamydia infections. Lymphogranuloma venereum tends to cause more severe inflammation and more aggressive infections compared to C trachomatis disorders from serovars A-K, where the resulting disease is typically relatively mild or asymptomatic. C trachomatis is a nonmotile, gram-negative intracellular bacterium that is transmissible through anal, oral, urethral, or vaginal contact. The bacterium is most frequently encountered in men who have sex with other men and is closely associated with HIV infections. Lymphogranuloma venereum most commonly presents with proctocolitis, which can be an invasive, systemic infection and progress to strictures, colorectal fistulas, rectal discharge, pain in the anus, tenesmus, and fever. Lymphogranuloma venereum is rare in the United States but is commonly found in subtropical and tropical regions worldwide. Lymphogranuloma venereum specific PCR-based testing confirms the diagnosis of lymphogranuloma venereum, but this may not be widely available. Therefore, the diagnosis is typically based on the history and physical findings, regional prevalence, nucleic acid amplification testing for C trachomatis from the affected anatomical site, clinical suspicion, and the exclusion of other etiologies. Patients presenting with severe proctocolitis symptoms, especially in endemic areas, should have a rectal specimen tested by nucleic acid amplification testing for C trachomatis. The Centers for Disease Control and Prevention recommends that all patients presenting with proctocolitis undergo appropriate diagnostic testing. The recommended treatment for lymphogranuloma venereum is antibiotic therapy, with doxycycline 100 mg twice daily for 21 days as the preferred regimen. Alternatives include erythromycin 500 mg four times daily for 21 days or…

Credit & MOC Details

Credit information is provided by the course provider. We recommend confirming credit eligibility with the provider or your licensing board before starting the activity.

Credit types

IPCE CreditsUp to 2 creditsAAPA Category 1 Credit™Up to 2 creditsAMA PRA Category 1 Credit™Up to 2 creditsNursingUp to 2 creditsPharmacyUp to 2 credits

MOC types

ABS — Accredited CMEUp to 2 pointsABPATH — Lifelong LearningUp to 2 pointsABTS — Accredited CMEUp to 2 pointsABIM — Medical KnowledgeUp to 2 pointsABS — Self-AssessmentUp to 2 pointsABP — Lifelong Learning and Self-AssessmentUp to 2 pointsABTS — Self-AssessmentUp to 2 points

FDA REMS

No

Qualifies for MIPS

No

Target Specialties

Cross-Specialty

Relevant across 8 specialties.

Pricing

Fee varies

This provider typically $49–98

See fees on statpearls.com

Listed by the provider

  • Article / monograph / reference
  • Credit · Up to 2 credits
  • MOC · Up to 2 points
  • Fee varies · this provider typically $49–98
  • Released
    Sep 1, 2026
  • Last day to claim credit
    Sep 1, 2029 3 years left

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