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StatPearls, LLC

  • Anemia, Macrocytic
  • Anemia, Megaloblastic
  • Folic Acid
  • Spherocytosis, Hereditary
  • Vitamin B 12

Macrocytic Anemia

Macrocytic anemia is a condition that occurs secondary to various underlying etiologies, characterized by an increased mean corpuscular volume (MCV >100 fL) in conjunction with anemia, defined by low hemoglobin or hematocrit levels. Macrocytic anemia is subcategorized into megaloblastic and nonmegaloblastic forms. Megaloblastic anemia, often caused by folate or vitamin B12 deficiencies, results from impaired DNA synthesis and is marked by hypersegmented neutrophils. Nonmegaloblastic anemia, which lacks hypersegmented neutrophils, can result from alcohol use, hereditary spherocytosis, hypothyroidism, liver disease, or conditions causing increased reticulocyte production. Some cases of macrocytosis are normal variants, while others result from laboratory artifacts. This course explores the clinical considerations surrounding this condition, including the diagnostic challenges secondary to varying symptomatic presentations, wide-ranging differential diagnoses, and targeted management approaches. Clinical presentation and treatment differ based on the underlying etiology. Therefore, an in-depth understanding of macrocytic anemia’s pathophysiology and resulting manifestations is essential. This activity for healthcare professionals is designed to enhance the learner’s competence in identifying macrocytic anemia, performing the recommended evaluation, and implementing an appropriate interprofessional approach when managing this condition.

Credit & MOC Details

Credit information is provided by the course provider. We recommend confirming credit eligibility with the provider or your licensing board before starting the activity.

Credit types

AAPA Category 1 Credit™Up to 1.5 creditsAMA PRA Category 1 Credit™Up to 1.5 creditsNursingUp to 1.5 creditsPharmacyUp to 1.5 credits

MOC types

ABS — Accredited CMEUp to 1.5 pointsABPATH — Lifelong LearningUp to 1.5 pointsABA — Lifelong LearningUp to 1.5 pointsABTS — Accredited CMEUp to 1.5 pointsABIM — Medical KnowledgeUp to 1.5 pointsABS — Self-AssessmentUp to 1.5 pointsABP — Lifelong Learning and Self-AssessmentUp to 1.5 pointsABTS — Self-AssessmentUp to 1.5 points

FDA REMS

No

Qualifies for MIPS

No

Target Specialties

Cross-Specialty

Relevant across 11 specialties.

Pricing

Fee varies

This provider typically $49–98

See fees on statpearls.com

Listed by the provider

  • Article / monograph / reference
  • Credit · Up to 1.5 credits
  • MOC · Up to 1.5 points
  • Fee varies · this provider typically $49–98
  • Released
    Sep 1, 2026
  • Last day to claim credit
    Sep 1, 2029 3 years left

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