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StatPearls, LLC

  • Hypoglycemia
  • Neonatal Screening
  • Sudden Infant Death

Medium-Chain Acyl-CoA Dehydrogenase Deficiency

Medium-chain acyl-CoA dehydrogenase deficiency (MCADD) is a rare autosomal recessive disorder characterized by mitochondrial fatty acid -oxidation impairment, leading to severe metabolic consequences. The inability to provide energy to tissues during glycogen depletion results in hypoketotic hypoglycemia, the hallmark presentation in young children. Additionally, MCADD may contribute to sudden infant death syndrome cases. While most individuals are asymptomatic at birth, the risk of morbidity and mortality is high during the initial episode. Newborn screening has significantly improved outcomes by preventing severe metabolic crises. However, there is currently no definitive treatment for MCADD, and management primarily involves dietary adjustments and emergency protocols during acute illness or stress. Clinicians must be proficient in identifying and managing MCADD to improve patient outcomes. Early diagnosis is critical, as it can dramatically improve prognosis and reduce medical care costs. Newborn screening via tandem mass spectrometry measures medium-chain acylcarnitines, aiding in early detection. Several tests can be used for diagnostic confirmation. Clinical management requires dietary adjustments and emergency response protocols during acute illness or stress. This activity for healthcare professionals aims to enhance learners’ competence in selecting appropriate diagnostic tests, managing MCADD, and fostering effective interprofessional teamwork to improve outcomes.

Credit & MOC Details

Credit information is provided by the course provider. We recommend confirming credit eligibility with the provider or your licensing board before starting the activity.

Credit types

IPCE CreditsUp to 2 creditsAAPA Category 1 Credit™Up to 2 creditsAMA PRA Category 1 Credit™Up to 2 creditsNursingUp to 2 creditsPharmacyUp to 2 credits

MOC types

ABS — Accredited CMEUp to 2 pointsABPATH — Lifelong LearningUp to 2 pointsABA — Lifelong LearningUp to 2 pointsABTS — Accredited CMEUp to 2 pointsABIM — Medical KnowledgeUp to 2 pointsABS — Self-AssessmentUp to 2 pointsABP — Lifelong Learning and Self-AssessmentUp to 2 pointsABTS — Self-AssessmentUp to 2 points

FDA REMS

No

Qualifies for MIPS

No

Target Specialties

Cross-Specialty

Relevant across 8 specialties.

Pricing

Fee varies

This provider typically $49–98

See fees on statpearls.com

Listed by the provider

  • Article / monograph / reference
  • Credit · Up to 2 credits
  • MOC · Up to 2 points
  • Fee varies · this provider typically $49–98
  • Released
    Sep 1, 2026
  • Last day to claim credit
    Sep 1, 2029 3 years left

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