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StatPearls, LLC

  • Cytomegalovirus Infections
  • Gastritis, Hypertrophic
  • Helicobacter Infections
  • Hypoalbuminemia
  • Nausea

Menetrier Disease

Ménétrier disease is a rare hypertrophic gastropathy characterized by giant mucosal folds predominantly involving the gastric body and fundus; reduced gastric acid secretion; and protein-losing enteropathy, leading to hypoalbuminemia. The disorder is associated with excessive transforming growth factor signaling and epidermal growth factor receptor activation, resulting in foveolar hyperplasia and glandular atrophy. In adults, Ménétrier disease typically follows a progressive course and carries an increased risk of gastric adenocarcinoma. In children, the condition is usually acute and self-limited and has been linked to cytomegalovirus infection. Helicobacter pylori infection has also been implicated, particularly in adults. Clinical manifestations include epigastric pain, nausea, vomiting, peripheral edema, weight loss, and anemia. Diagnosis is based on endoscopic visualization of enlarged gastric folds, histopathologic confirmation, and exclusion of mimicking conditions. Management focuses on supportive care, treatment of underlying infections when present, acid suppression, nutritional support, and targeted interventions, such as epidermal growth factor receptor inhibitor administration, in refractory cases. Complications include severe protein malnutrition and gastric malignancy, with prognosis dependent on age of onset and response to therapy. This activity for healthcare professionals is designed to improve learners’ competence in evaluating and managing Ménétrier disease. Participants will advance their mastery of the condition’s etiology, risk factors, pathophysiology, clinical presentation, and evidence-based diagnostic and therapeutic approaches. Greater skills will equip clinicians to collaborate with interprofessional teams providing care for affected individuals.

Credit & MOC Details

Credit information is provided by the course provider. We recommend confirming credit eligibility with the provider or your licensing board before starting the activity.

Credit types

AAPA Category 1 Credit™Up to 1 creditAMA PRA Category 1 Credit™Up to 1 creditNursingUp to 1 creditPharmacyUp to 1 credit

MOC types

ABS — Accredited CMEUp to 1 pointABPATH — Lifelong LearningUp to 1 pointABTS — Accredited CMEUp to 1 pointABIM — Medical KnowledgeUp to 1 pointABS — Self-AssessmentUp to 1 pointABP — Lifelong Learning and Self-AssessmentUp to 1 pointABTS — Self-AssessmentUp to 1 point

FDA REMS

No

Qualifies for MIPS

No

Target Specialties

Pricing

Fee varies

This provider typically $49–98

See fees on statpearls.com

Listed by the provider

  • Article / monograph / reference
  • Credit · Up to 1 credit
  • MOC · Up to 1 point
  • Fee varies · this provider typically $49–98
  • Released
    Sep 1, 2026
  • Last day to claim credit
    Sep 1, 2029 3 years left

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