Epinephrine
Neurofibromatosis 1
Nevus
Norepinephrine
Vitiligo

Nevus Anemicus

Nevus anemicus is an uncommon congenital vascular malformation that results in hypopigmented cutaneous macules and patches, which characteristically do not become erythematous in response to trauma, heat, or cold. Nevus anemicus typically presents as an isolated lesion with no other systemic manifestations and is attributed to the increased sensitivity of cutaneous blood vessels to catecholamines such as epinephrine and norepinephrine. This hypersensitivity leads to permanent vasoconstriction, causing hyperpigmentation. Clinically, nevus anemicus often presents as a pale macule or patch that is noticeable from birth and grows with the individual. Diascopy can help distinguish nevus anemicus from other segmental hypomelanoses, such as vitiligo and hypochromic nevi. Nevus anemicus lesions are often discovered incidentally during a skin examination. Stroking or rubbing the surrounding skin can make subtle lesions more noticeable. Diagnosis involves recognizing its clinical features and ruling out other conditions using a Wood lamp and possibly a skin biopsy. Nevus anemicus requires no treatment, although cosmetic camouflage makeup may be beneficial, particularly for facial lesions. The prognosis for nevus anemicus is favorable. However, its presence in a child with multiple café-au-lait macules should raise suspicion of neurofibromatosis type 1. This activity provides healthcare professionals with a comprehensive understanding of nevus anemicus, including its pathophysiology, clinical presentation, causative mechanisms, differential diagnosis, and management strategies, as well as guidance on when further intervention or referral is needed. This activity also highlights the role of an interprofessional healthcare team in enhancing diagnostic accuracy and clinical outcomes for patients with nevus anemicus.

Credit & MOC Details

Credit information is provided by the course provider. We recommend confirming credit eligibility with the provider or your licensing board before starting the activity.