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StatPearls, LLC

  • Anti-Inflammatory Agents, Non-Steroidal
  • Epoprostenol
  • Fever
  • Inflammation

Nonsteroidal Anti-Inflammatory Drugs Toxicity

Nonsteroidal anti-inflammatory drugs (NSAIDs) are a diverse class of medications that, despite chemical differences, share common therapeutic and adverse effects. They primarily alleviate inflammation, pain, and fever by inhibiting cyclooxygenase (COX) enzymes, which are crucial in the biosynthesis of prostanoids. The two primary COX isozymes, COX-1 and COX-2, convert arachidonic acid into prostaglandins, prostacyclin, and thromboxane molecules involved in various physiological processes, including inflammation, regulation of smooth muscle tone, and thrombosis. COX-1 is constitutively expressed and plays a crucial role in maintaining physiological functions, such as gastric mucosal protection. In contrast, COX-2 is inducible, and its expression increases during inflammatory states. While NSAIDs’ inhibition of these enzymes underlies their therapeutic benefits, it also contributes to potential toxicities. This activity provides an updated review of the etiology, presentation, evaluation, and management of NSAID toxicity, highlighting the role of the interprofessional team in managing this condition.

Credit & MOC Details

Credit information is provided by the course provider. We recommend confirming credit eligibility with the provider or your licensing board before starting the activity.

Credit types

AAPA Category 1 Credit™Up to 1.5 creditsAMA PRA Category 1 Credit™Up to 1.5 creditsNursingUp to 1.5 creditsPharmacyUp to 1.5 credits

MOC types

ABS — Accredited CMEUp to 1.5 pointsABOS — Accredited CMEUp to 1.5 pointsABPM — Accredited CMEUp to 1.5 pointsABPATH — Lifelong LearningUp to 1.5 pointsABA — Lifelong LearningUp to 1.5 pointsABTS — Accredited CMEUp to 1.5 pointsABIM — Medical KnowledgeUp to 1.5 pointsABS — Self-AssessmentUp to 1.5 pointsABP — Lifelong Learning and Self-AssessmentUp to 1.5 pointsABPM — Self-AssessmentUp to 1.5 pointsABOHNS — Self-AssessmentUp to 1.5 pointsABTS — Self-AssessmentUp to 1.5 points

FDA REMS

No

Qualifies for MIPS

No

Target Specialties

Cross-Specialty

Relevant across 10 specialties.

Pricing

Fee varies

This provider typically $49–98

See fees on statpearls.com

Listed by the provider

  • Article / monograph / reference
  • Credit · Up to 1.5 credits
  • MOC · Up to 1.5 points
  • Fee varies · this provider typically $49–98
  • Released
    Sep 1, 2026
  • Last day to claim credit
    Sep 1, 2029 3 years left

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