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StatPearls, LLC

  • Acrocephalosyndactylia
  • Long-Term Care

Pfeiffer Syndrome

Pfeiffer syndrome is a rare, inherited craniofacial disorder characterized by multisutural craniosynostosis, midface hypoplasia, broad thumbs, great toes, and soft tissue syndactyly of the hands and feet. Also known as type V acrocephalosyndactyly, Pfeiffer syndrome is the second most common condition in this group after Apert syndrome. The condition results from mutations in the fibroblast growth factor receptor genes FGFR1 and FGFR2, which play a key role in bone development. Pfeiffer syndrome is clinically classified into 3 types: type 1, the classic form, is typically associated with normal intelligence and a favorable prognosis, whereas types 2 and 3 are more severe, often leading to significant neurological impairment and early mortality. Type 2 is notably associated with a cloverleaf skull deformity, a hallmark of severe craniosynostosis. This continuing education activity provides a comprehensive overview of Pfeiffer syndrome, including its epidemiology, genetic basis, clinical presentation, and treatment strategies. With multi-system involvement affecting cranial, facial, airway, auditory, and skeletal development, optimal care for individuals with Pfeiffer syndrome requires a coordinated, interdisciplinary approach. This activity highlights the importance of collaboration across specialties in supporting timely diagnosis, effective surgical planning, and comprehensive long-term care, ultimately enhancing outcomes and quality of life for affected patients and their families.

Credit & MOC Details

Credit information is provided by the course provider. We recommend confirming credit eligibility with the provider or your licensing board before starting the activity.

Credit types

AAPA Category 1 Credit™Up to 1.5 creditsAMA PRA Category 1 Credit™Up to 1.5 creditsNursingUp to 1.5 creditsPharmacyUp to 1.5 credits

MOC types

ABS — Accredited CMEUp to 1.5 pointsABOS — Accredited CMEUp to 1.5 pointsABPATH — Lifelong LearningUp to 1.5 pointsABA — Lifelong LearningUp to 1.5 pointsABTS — Accredited CMEUp to 1.5 pointsABS — Self-AssessmentUp to 1.5 pointsABP — Lifelong Learning and Self-AssessmentUp to 1.5 pointsABOHNS — Self-AssessmentUp to 1.5 pointsABTS — Self-AssessmentUp to 1.5 points

FDA REMS

No

Qualifies for MIPS

No

Target Specialties

Cross-Specialty

Relevant across 8 specialties.

Pricing

Fee varies

This provider typically $49–98

See fees on statpearls.com

Listed by the provider

  • Article / monograph / reference
  • Credit · Up to 1.5 credits
  • MOC · Up to 1.5 points
  • Fee varies · this provider typically $49–98
  • Released
    Sep 1, 2026
  • Last day to claim credit
    Sep 1, 2029 3 years left

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