Postinflammatory hyperpigmentation is a common acquired disorder that occurs following skin inflammation or injury. The condition is chronic and is more common and severe in individuals with darker skin tones, especially those with Fitzpatrick skin types III to VI, due to increased melanin production or irregular melanin deposition in response to skin inflammation or injury. Postinflammatory hyperpigmentation results from overproduction and irregular dispersion of melanin in the epidermis or dermis, triggered by various skin insults, such as acne, eczema, trauma, or dermatologic procedures. The intensity and duration of pigmentation vary, influenced by factors such as the depth of melanin deposition and the individual’s skin type. Understanding postinflammatory hyperpigmentation’s pathogenesis and recognizing predisposing factors are essential in managing and preventing this often distressing condition, especially in individuals with darker skin tones. Although the condition typically improves spontaneously, this process can take months to years, necessitating prolonged treatment. The extent and persistence of postinflammatory hyperpigmentation depend on the degree of inflammation and the depth of melanin deposition, with darker skin types being more susceptible due to a greater baseline level of melanin production and more reactive melanocytes. This activity reviews the evaluation and management of postinflammatory hyperpigmentation, highlighting the role of the interprofessional team in educating and treating patients with this condition. This activity describes the epidemiology, genetics, clinical presentation, and management of postinflammatory hyperpigmentation, providing clinicians with the knowledge and tools to improve patient care for this complex and prevalent condition.
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