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StatPearls, LLC

  • Birth Weight
  • Mediastinal Emphysema
  • Noninvasive Ventilation
  • Pneumopericardium
  • Respiration, Artificial

Pulmonary Interstitial Emphysema

Pulmonary interstitial emphysema (PIE) is a rare but clinically significant lung condition that predominantly affects premature infants, although it can also occur in adults. Infants with low birth weight and prematurity are at increased risk for PIE, underscoring the need for early recognition and timely intervention. PIE is characterized by alveolar and airway over-distention, resulting in air leakage into the interstitial and bronchovascular spaces, which disrupts normal lung architecture and may lead to severe complications such as pneumothorax or pneumopericardium. PIE often occurs in neonates with respiratory distress syndrome and is typically diagnosed through radiological imaging, which reveals linear or cystic air-filled lucencies in the lung parenchyma. Clinicians should adopt a comprehensive diagnostic approach that includes exclusionary criteria, detailed physical examinations, and targeted imaging to improve diagnostic accuracy. Management strategies include the use of prophylactic surfactant therapy, noninvasive ventilation techniques, and, in refractory cases, mechanical ventilation or surgical options such as lobectomy. This activity reviews the epidemiology, etiology, clinical manifestations, and diagnostic challenges of PIE, with an emphasis on its potentially severe consequences in neonates. This activity also explores current, evidence-based, and multifaceted treatment approaches while highlighting key contraindications to mechanical ventilation. Additionally, the activity provides healthcare providers valuable insights into various management strategies, enhancing their ability to collaborate effectively within interprofessional teams.

Credit & MOC Details

Credit information is provided by the course provider. We recommend confirming credit eligibility with the provider or your licensing board before starting the activity.

Credit types

IPCE CreditsUp to 1.5 creditsAAPA Category 1 Credit™Up to 1.5 creditsAMA PRA Category 1 Credit™Up to 1.5 creditsNursingUp to 1.5 creditsPharmacyUp to 1.5 credits

MOC types

ABS — Accredited CMEUp to 1.5 pointsABPATH — Lifelong LearningUp to 1.5 pointsABA — Lifelong LearningUp to 1.5 pointsABTS — Accredited CMEUp to 1.5 pointsABIM — Medical KnowledgeUp to 1.5 pointsABS — Self-AssessmentUp to 1.5 pointsABP — Lifelong Learning and Self-AssessmentUp to 1.5 pointsABTS — Self-AssessmentUp to 1.5 points

FDA REMS

No

Qualifies for MIPS

No

Target Specialties

Cross-Specialty

Relevant across 11 specialties.

Pricing

Fee varies

This provider typically $49–98

See fees on statpearls.com

Listed by the provider

  • Article / monograph / reference
  • Credit · Up to 1.5 credits
  • MOC · Up to 1.5 points
  • Fee varies · this provider typically $49–98
  • Released
    Sep 1, 2026
  • Last day to claim credit
    Sep 1, 2029 3 years left

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