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StatPearls, LLC

  • Cell Transplantation
  • Reinfection

X-Linked Immunodeficiency

Primary immunodeficiencies are a diverse group of more than 450 genetic disorders that impair innate and adaptive immunity, leading to recurrent infections, autoimmune disease, lymphoproliferation, inflammatory complications, and an increased risk of malignancy. This course reviews the primary 7 X-linked conditions among them that are particularly severe, often presenting in early childhood with characteristic infection patterns, immune dysfunction, and multisystem involvement. Targeted immunologic evaluation and genetic confirmation, which remain essential for reducing morbidity and enabling timely curative interventions such as hematopoietic cell transplantation or emerging gene-based therapies, are also discussed. This activity provides an overview of X-linked primary immunodeficiencies, emphasizing clinical presentation, diagnostic strategies, and evidence-based management. Participants will also gain an understanding of the early warning signs, interpretation of laboratory and genetic findings, and coordination of interprofessional care for affected patients. This activity for healthcare professionals is designed to enhance the learner’s competence in identifying X-linked immunodeficiencies, performing the recommended evaluation, selecting antimicrobial prophylaxis and immunoglobulin replacement, determining immunomodulatory therapy, integrating transplant considerations, and implementing an appropriate interprofessional approach when managing this condition to improve long-term outcomes for patients with complex immune disorders.

Credit & MOC Details

Credit information is provided by the course provider. We recommend confirming credit eligibility with the provider or your licensing board before starting the activity.

Credit types

AAPA Category 1 Credit™Up to 2 creditsAMA PRA Category 1 Credit™Up to 2 creditsNursingUp to 2 creditsPharmacyUp to 2 credits

MOC types

ABS — Accredited CMEUp to 2 pointsABPATH — Lifelong LearningUp to 2 pointsABTS — Accredited CMEUp to 2 pointsABIM — Medical KnowledgeUp to 2 pointsABS — Self-AssessmentUp to 2 pointsABP — Lifelong Learning and Self-AssessmentUp to 2 pointsABTS — Self-AssessmentUp to 2 points

FDA REMS

No

Qualifies for MIPS

No

Target Specialties

Cross-Specialty

Relevant across 11 specialties.

Pricing

Fee varies

This provider typically $49–98

See fees on statpearls.com

Listed by the provider

  • Article / monograph / reference
  • Credit · Up to 2 credits
  • MOC · Up to 2 points
  • Fee varies · this provider typically $49–98
  • Released
    Sep 1, 2026
  • Last day to claim credit
    Sep 1, 2029 3 years left

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