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StatPearls, LLC

  • Arginine
  • Cerebral Palsy
  • Hyperammonemia
  • Hyperargininemia
  • Spastic Paraplegia, Hereditary

Arginase Deficiency

Arginase deficiency, also called argininemia, is a rare autosomal recessive urea cycle disorder characterized by toxic arginine accumulation and progressive neurologic injury. The condition is frequently misdiagnosed as cerebral palsy or hereditary spastic paraplegia because hyperammonemia may be mild, intermittent, or absent. This continuing medical education activity reviews the limitations of newborn screening, clinical presentation, biochemical findings, molecular confirmation, acute hyperammonemia treatment, lifelong arginine-lowering strategies, enzyme replacement therapy, supportive care, and genetic counseling. The activity addresses the gap between evidence-based standards and delayed or incomplete recognition of argininemia. Participants will strengthen diagnostic reasoning, differentiate argininemia from proximal urea cycle disorders, select individualized treatment, prevent irreversible complications, counsel families effectively, and coordinate interprofessional care to improve patient-centered outcomes.

Credit & MOC Details

Credit information is provided by the course provider. We recommend confirming credit eligibility with the provider or your licensing board before starting the activity.

Credit types

AAPA Category 1 Credit™Up to 1.5 creditsAMA PRA Category 1 Credit™Up to 1.5 creditsNursingUp to 1.5 creditsPharmacyUp to 1.5 credits

MOC types

ABS — Accredited CMEUp to 1.5 pointsABPATH — Lifelong LearningUp to 1.5 pointsABA — Lifelong LearningUp to 1.5 pointsABTS — Accredited CMEUp to 1.5 pointsABIM — Medical KnowledgeUp to 1.5 pointsABS — Self-AssessmentUp to 1.5 pointsABP — Lifelong Learning and Self-AssessmentUp to 1.5 pointsABTS — Self-AssessmentUp to 1.5 points

FDA REMS

No

Qualifies for MIPS

No

Target Specialties

Cross-Specialty

Relevant across 10 specialties.

Pricing

Fee varies

This provider typically $49–98

See fees on statpearls.com

Listed by the provider

  • Article / monograph / reference
  • Credit · Up to 1.5 credits
  • MOC · Up to 1.5 points
  • Fee varies · this provider typically $49–98
  • Released
    Sep 1, 2026
  • Last day to claim credit
    Sep 1, 2029 3 years left

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