In this case-based discussion, Drs. Kenar Jhaveri and Shikha Wadhwani examine individualized treatment strategies for adults with C3 glomerulopathy (C3G) or primary immune complex membranoproliferative glomerulonephritis (IC-MPGN). Using a patient with limited response to factor B inhibition, the faculty review the current standard of care, its limitations, and considerations for switching complement-targeted therapy. The discussion examines pegcetacoplan and clinical evidence presented at ERA, including pharmacokinetic and exposure-response analyses and findings from VALIANT/VALE on proteinuria and eGFR through 52 weeks.
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FDA REMS
Qualifies for MIPS
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CME included with membership
| Free Registration | Free |
| Tufts-Affiliated HCP - Early Bird (by 10/5/26) | $75 |
| Tufts-Affiliated HCP - Standard | $175 |
| Trainees & Allied Health - Early Bird (by 10/5/26) | $75 |
| Trainees & Allied Health - Standard | $175 |
| Physicians - Early Bird (by 10/5/26) | $150 |
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Specialties served/covered
- Advanced Heart Failure & Transplant Cardiology
- Allergy & Clinical Immunology
- Cardiovascular Disease
- Communication & Shared Decision-Making
- Dermatology
- Diagnostic Radiology
- Endocrinology, Diabetes & Metabolism
- Family Medicine
- Gastroenterology
- General & Adult Psychiatry
- General Pediatrics
- Gynecologic Oncology
- Head & Neck Surgery
- Hematology
- Maternal-Fetal Medicine
- Medical Genetics & Genomics
- Medical Oncology
- Mood & Anxiety Disorders
- Nephrology
- Neurology
- Neuromuscular Medicine
- Neuroradiology
- Obstetrics & Gynecology
- Ophthalmology
- Pediatric Neurology
- Psychopharmacology
- Psychotic Disorders
- Pulmonary Disease
- Radiation Oncology
- Rheumatology
- Sleep Medicine
- Surgical Oncology
- Transplant Hepatology
- Urological Oncology
- Vascular Neurology
- Cardio-Vascular
- Cross-Specialty
- ENT & Head Neck
- GI & Liver
- Medical Subspecialties
- Neurology
- Ob/Gyn
- Oncology & Hematology
- Pediatrics
- Primary care
- Psychiatry
- Radiology
- Surgery
- Urology
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Pricing
Free
Reported to ACCME by the provider
- Case-based learning
- Credit · Up to 0.25 credits
- Commercial Support
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Available fromOct 20, 2026
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Last day to claim creditOct 21, 2027 1 year left
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National Kidney Foundation An Update on C3G and IC-MPGN Management
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PeerVoice, Siyemi Europe Limited PeerVoice – C3G and IC-MPGN Clinically Considered: A Real World Case Based Masterclass in Complement Inhibition
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P2P Syncro +1 From Common Renal and Urinary Signs to Diagnosing and Treating C3G and IC-MPGN
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Global Learning Collaborative Engaging Adult Patients With C3GN: Shared Decision-Making at the Crossroads of Complement-Targeted Therapy
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Global Learning Collaborative Transforming Care in Pediatric Patients With C3 Glomerulopathy: Targeting C3 at the Source
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Global Learning Collaborative Optimizing Outcomes in Patients With FSGS: A Case-Based Approach in the New Era of Targeted Therapy
