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StatPearls, LLC

  • Bosentan
  • Cardiac Output
  • Endothelin Receptor Antagonists
  • Headache
  • Pulmonary Arterial Hypertension

Bosentan

Pulmonary arterial hypertension (PAH) contributes substantially to global morbidity and mortality due to progressive vascular remodeling and increased pulmonary vascular resistance. Endothelin 1 overexpression plays a central role in vasoconstriction, smooth muscle proliferation, and endothelial dysfunction in affected patients. Bosentan, a dual endothelin receptor antagonist, mitigates these pathogenic processes by competitively inhibiting endothelin A and B receptors, thereby reducing pulmonary arterial pressure and improving cardiac output. Clinical indications include idiopathic and heritable PAH, as well as PAH arising from connective tissue disease or congenital heart defects. Randomized controlled trials have demonstrated bosentan s efficacy in improving exercise capacity, functional class, and hemodynamic parameters. Administration requires oral dosing with careful titration and periodic liver function monitoring due to potential hepatotoxicity. Common adverse effects include peripheral edema, headache, and anemia. Bosentan s integration into PAH management has significantly altered disease progression and patient outcomes, establishing endothelin receptor antagonism as a cornerstone of 1st-line therapy. This activity for healthcare professionals is designed to improve learners’ proficiency in the safe and effective use of bosentan. Participants will deepen their understanding of this drug’s mechanism of action, evidence base, indications, off-label applications, administration, efficacy, safety profile, monitoring parameters, comparative effectiveness, and clinical considerations. Enhanced competence will equip clinicians to collaborate successfully with interprofessional teams in optimizing PAH therapy and tailoring treatment to individual patient needs.

Credit & MOC Details

Credit information is provided by the course provider. We recommend confirming credit eligibility with the provider or your licensing board before starting the activity.

Credit types

AAPA Category 1 Credit™Up to 1.5 creditsAMA PRA Category 1 Credit™Up to 1.5 creditsNursingUp to 1.5 creditsPharmacyUp to 1.5 credits

MOC types

ABS — Accredited CMEUp to 1.5 pointsABPATH — Lifelong LearningUp to 1.5 pointsABA — Lifelong LearningUp to 1.5 pointsABTS — Accredited CMEUp to 1.5 pointsABIM — Medical KnowledgeUp to 1.5 pointsABS — Self-AssessmentUp to 1.5 pointsABP — Lifelong Learning and Self-AssessmentUp to 1.5 pointsABTS — Self-AssessmentUp to 1.5 points

FDA REMS

No

Qualifies for MIPS

No

Target Specialties

Cross-Specialty

Relevant across 8 specialties.

Pricing

Fee varies

This provider typically $49–98

See fees on statpearls.com

Listed by the provider

  • Article / monograph / reference
  • Credit · Up to 1.5 credits
  • MOC · Up to 1.5 points
  • Fee varies · this provider typically $49–98
  • Released
    Sep 1, 2026
  • Last day to claim credit
    Sep 1, 2029 3 years left

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