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StatPearls, LLC

  • Bradycardia
  • Calcium Channel Blockers
  • Coronary Artery Disease
  • Hyperkalemia
  • Renal Insufficiency

BRASH Syndrome

BRASH syndrome an acronym for bradycardia, renal failure, atrioventricular nodal blockade, shock, and hyperkalemia is a life-threatening condition resulting from the interplay between atrioventricular nodal blocking medications and kidney injury. This negative synergy triggers severe hyperkalemia and bradycardia, creating a self-perpetuating cycle that demands prompt recognition and intervention. Although the acronym is relatively new, the association between atrioventricular nodal blockers and renal dysfunction has been recognized for decades. Atrioventricular nodal blocking agents, including -blockers and calcium channel blockers, have been used since the 1960s to treat conditions such as coronary artery disease, hypertension, and tachyarrhythmias. Despite their clinical efficacy, these agents can lead to adverse effects, including BRASH syndrome, an underdiagnosed complication with high morbidity and mortality risk. This activity reviews the pathophysiology, clinical presentation, and management of BRASH syndrome, emphasizing the need for early recognition and tailored treatment strategies. The role of the interprofessional healthcare team in diagnosing and managing this condition is highlighted to optimize patient outcomes.

Credit & MOC Details

Credit information is provided by the course provider. We recommend confirming credit eligibility with the provider or your licensing board before starting the activity.

Credit types

AAPA Category 1 Credit™Up to 1 creditAMA PRA Category 1 Credit™Up to 1 creditNursingUp to 1 creditPharmacyUp to 1 credit

MOC types

ABS — Accredited CMEUp to 1 pointABPATH — Lifelong LearningUp to 1 pointABA — Lifelong LearningUp to 1 pointABTS — Accredited CMEUp to 1 pointABIM — Medical KnowledgeUp to 1 pointABS — Self-AssessmentUp to 1 pointABP — Lifelong Learning and Self-AssessmentUp to 1 pointABTS — Self-AssessmentUp to 1 point

FDA REMS

No

Qualifies for MIPS

No

Target Specialties

Cross-Specialty

Relevant across 8 specialties.

Pricing

Fee varies

This provider typically $49–98

See fees on statpearls.com

Listed by the provider

  • Article / monograph / reference
  • Credit · Up to 1 credit
  • MOC · Up to 1 point
  • Fee varies · this provider typically $49–98
  • Released
    Sep 1, 2026
  • Last day to claim credit
    Sep 1, 2029 3 years left

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