StatPearls, LLC

  • Diphenhydramine
  • Dystonia
  • Histamine Antagonists
  • Sleep Initiation and Maintenance Disorders
  • Vertigo

Diphenhydramine

This activity provides healthcare professionals with an in-depth review of diphenhydramine, a first-generation antihistamine commonly prescribed to manage allergic disorders, insomnia, pruritus, urticaria, vertigo, motion sickness, and dystonias. Clinical applications, mechanism of action, adverse effects, contraindications, and off-label uses receive focused attention, ensuring healthcare professionals understand the broad range of conditions where diphenhydramine may play a role. Pharmacokinetics, administration strategies, and clinically significant drug interactions are reviewed to support safe and effective prescribing practices. This activity also addresses diphenhydramine s toxicity profile, highlighting risks associated with inappropriate dosing, drug interactions, and patient-specific factors. Evidence-based strategies for optimizing therapeutic benefits while minimizing adverse outcomes are discussed in detail. Healthcare professionals gain essential information to adjust dosing regimens, recognize contraindications, and make informed treatment decisions. By enhancing understanding of diphenhydramine s clinical utility and safety considerations, this activity supports improved patient care and safer prescribing practices across various care settings.

Credit & MOC Details

Credit information is provided by the course provider. We recommend confirming credit eligibility with the provider or your licensing board before starting the activity.

Credit types

AAPA Category 1 Credit™Up to 1.5 creditsAMA PRA Category 1 Credit™Up to 1.5 creditsNursingUp to 1.5 creditsPharmacyUp to 1.5 credits

MOC types

ABS — Accredited CMEUp to 1.5 pointsABOS — Accredited CMEUp to 1.5 pointsABPATH — Lifelong LearningUp to 1.5 pointsABA — Lifelong LearningUp to 1.5 pointsABTS — Accredited CMEUp to 1.5 pointsABIM — Medical KnowledgeUp to 1.5 pointsABS — Self-AssessmentUp to 1.5 pointsABP — Lifelong Learning and Self-AssessmentUp to 1.5 pointsABOHNS — Self-AssessmentUp to 1.5 pointsABTS — Self-AssessmentUp to 1.5 points

FDA REMS

No

Qualifies for MIPS

No

Target Specialties

Cross-Specialty

Relevant across 12 specialties.

Pricing

Fee varies

This provider typically $49–98

See fees on statpearls.com

Listed by the provider

  • Article / monograph / reference
  • Credit · Up to 1.5 credits
  • MOC · Up to 1.5 points
  • Fee varies · this provider typically $49–98
  • Released
    Sep 1, 2026
  • Last day to claim credit
    Sep 1, 2029 3 years left