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StatPearls, LLC

  • Dermatitis, Exfoliative
  • Genetic Testing
  • Hyperkeratosis, Epidermolytic
  • Reinfection

Epidermolytic Hyperkeratosis

Epidermolytic hyperkeratosis, also referred to as “bullous ichthyosiform erythroderma,” is a rare autosomal dominant disorder of cornification caused by mutations in keratins 1 and 10. The condition is characterized by erythroderma and blistering at birth, with subsequent development of hyperkeratosis. Epidermolytic hyperkeratosis typically presents at birth or early infancy with widespread blistering, skin fragility, and scaling, especially in areas often exposed to friction, such as the palms, soles, and joints. Blistering may decrease over time, but hyperkeratosis, or thickened, scaly skin, often persists and can worsen with age. Patients may experience recurrent infections in affected areas due to skin breakdown and fragility. Diagnosis of epidermolytic hyperkeratosis requires clinical examination, genetic testing, and, sometimes, a skin biopsy to confirm characteristic keratin mutations. Management includes topical keratolytics, moisturizers, and retinoids to reduce scaling, along with infection treatment or prevention measures. Epidermolytic hyperkeratosis has no cure. Symptoms may be managed effectively, though the condition may cause psychosocial difficulties in growing individuals. This activity for healthcare professionals is designed to enhance learners’ competence in evaluating and managing epidermolytic hyperkeratosis. Trainees will gain a deeper understanding of the condition’s etiology, pathophysiology, presentation, and recommended diagnostic and therapeutic practices. Greater proficiency will equip clinicians to collaborate within an interprofessional team caring for patients with this condition.

Credit & MOC Details

Credit information is provided by the course provider. We recommend confirming credit eligibility with the provider or your licensing board before starting the activity.

Credit types

AAPA Category 1 Credit™Up to 1 creditAMA PRA Category 1 Credit™Up to 1 creditNursingUp to 1 creditPharmacyUp to 1 credit

MOC types

ABS — Accredited CMEUp to 1 pointABPATH — Lifelong LearningUp to 1 pointABTS — Accredited CMEUp to 1 pointABIM — Medical KnowledgeUp to 1 pointABS — Self-AssessmentUp to 1 pointABP — Lifelong Learning and Self-AssessmentUp to 1 pointABTS — Self-AssessmentUp to 1 point

FDA REMS

No

Qualifies for MIPS

No

Target Specialties

Cross-Specialty

Relevant across 6 specialties.

Pricing

Fee varies

This provider typically $49–98

See fees on statpearls.com

Listed by the provider

  • Article / monograph / reference
  • Credit · Up to 1 credit
  • MOC · Up to 1 point
  • Fee varies · this provider typically $49–98
  • Released
    Sep 1, 2026
  • Last day to claim credit
    Sep 1, 2029 3 years left

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