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StatPearls, LLC

  • Antidotes
  • Antineoplastic Agents
  • Fluorouracil
  • Leucovorin
  • Methotrexate

Folinic Acid

Folinic acid, also known as 5-formyl tetrahydrofolic acid or leucovorin, treats various cancers when employed with 5-fluorouracil (5-FU). Additionally, leucovorin serves as an antidote to folic acid antagonists like methotrexate. Folinic acid’s properties allow it to function as an antidote, chemotherapy-modulating agent, and rescue agent for the chemotherapy category of medications. This activity will discuss the approved indications, intricate mechanism of action, and contraindications for folinic acid while addressing its role in treating specific cancer types and megaloblastic anemia. The activity will also discuss the adverse event profile, off-label applications, and monitoring protocols associated with folinic acid, offering insights for the interprofessional team involved in the care of patients undergoing treatment with 5-FU, methotrexate, and other conditions where folinic acid proves indispensable.

Credit & MOC Details

Credit information is provided by the course provider. We recommend confirming credit eligibility with the provider or your licensing board before starting the activity.

Credit types

AAPA Category 1 Credit™Up to 1.5 creditsAMA PRA Category 1 Credit™Up to 1.5 creditsNursingUp to 1.5 creditsPharmacyUp to 1.5 credits

MOC types

ABS — Accredited CMEUp to 1.5 pointsABPATH — Lifelong LearningUp to 1.5 pointsABTS — Accredited CMEUp to 1.5 pointsABIM — Medical KnowledgeUp to 1.5 pointsABS — Self-AssessmentUp to 1.5 pointsABP — Lifelong Learning and Self-AssessmentUp to 1.5 pointsABTS — Self-AssessmentUp to 1.5 points

FDA REMS

No

Qualifies for MIPS

No

Target Specialties

Cross-Specialty

Relevant across 9 specialties.

Pricing

Fee varies

This provider typically $49–98

See fees on statpearls.com

Listed by the provider

  • Article / monograph / reference
  • Credit · Up to 1.5 credits
  • MOC · Up to 1.5 points
  • Fee varies · this provider typically $49–98
  • Released
    Sep 1, 2026
  • Last day to claim credit
    Sep 1, 2029 3 years left

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