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StatPearls, LLC

  • Anosmia
  • Gonadotropin-Releasing Hormone
  • Kallmann Syndrome
  • Puberty, Delayed
  • Vitamin D

Kallmann Syndrome

Kallmann syndrome is a congenital form of hypogonadism caused by low levels of hypogonadotropic hormones. In addition to incomplete or delayed puberty and infertility, it characteristically manifests with hyposmia or anosmia from birth. The decrease in gonadal function is due to a failure in the differentiation or migration of neurons that arise embryologically in the olfactory mucosa and normally take up residence in the hypothalamus to serve as gonadotropin-releasing hormone neurons. Although no definitive biomarker is available, a family history of delayed puberty may be present, and case reports have identified genetic differences in patients. Decreased levels of sex steroids result from the deficit in gonadotropin-releasing hormone and lead to the prominent signs and symptoms of a lack of sexual maturity and the absence of secondary sexual characteristics. Typical diagnosis occurs when a child fails to begin puberty. The condition, first described in the modern era in 1944, is a rare, X-linked genetic disease that is estimated to affect 1 in 48,000 individuals and is 4 times more prevalent in males compared to females. Treatment involves life-long hormone replacement therapy and may include surgery for male patients to correct undescended testicles. Patients have an increased risk of developing osteoporosis later in life due to decreased sexual hormone production and are often prescribed vitamin D supplementation and bisphosphonates. This activity reviews the evaluation and treatment of Kallmann syndrome and discusses the role of the interprofessional team in evaluating and treating patients with this condition.

Credit & MOC Details

Credit information is provided by the course provider. We recommend confirming credit eligibility with the provider or your licensing board before starting the activity.

Credit types

AAPA Category 1 Credit™Up to 2 creditsAMA PRA Category 1 Credit™Up to 2 creditsNursingUp to 2 creditsPharmacyUp to 2 credits

MOC types

ABS — Accredited CMEUp to 2 pointsABPATH — Lifelong LearningUp to 2 pointsABTS — Accredited CMEUp to 2 pointsABIM — Medical KnowledgeUp to 2 pointsABS — Self-AssessmentUp to 2 pointsABP — Lifelong Learning and Self-AssessmentUp to 2 pointsABOHNS — Self-AssessmentUp to 2 pointsABTS — Self-AssessmentUp to 2 points

FDA REMS

No

Qualifies for MIPS

No

Target Specialties

Cross-Specialty

Relevant across 8 specialties.

Pricing

Fee varies

This provider typically $49–98

See fees on statpearls.com

Listed by the provider

  • Article / monograph / reference
  • includes Case study / clinical scenario
  • Credit · Up to 2 credits
  • MOC · Up to 2 points
  • Fee varies · this provider typically $49–98
  • Released
    Sep 1, 2026
  • Last day to claim credit
    Sep 1, 2029 3 years left

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