Personalizing Therapy in a Complex MuSK+ Patient

Generalized myasthenia gravis (gMG) disrupts neuromuscular transmission, creating unpredictable symptom flare-ups and placing a significant burden on patients with this rare condition. Most commonly associated with antibodies targeting the acetylcholine receptor (AChR), and less commonly with muscle specific kinase (MuSK) or low-density lipoprotein receptor related protein 4 (LRP4), gMG has forced patients and clinicians to navigate treatments that can be difficult to tolerate, slow to act, or limited by safety concerns. The recent approval of innovative neonatal Fc receptor (FcRn) antagonists offers the potential for faster symptom control and improved quality of life. Clinicians, however, may often lack evidence-based guidance and confidence to initiate and tailor FcRn antagonist therapy, especially in complex MuSK+ patients with steroid toxicity, which may contribute to delayed use of effective, steroid-sparing options as well as suboptimal shared decision-making. Targeted education can help clinicians and multidisciplinary care teams integrate these agents into individualized care plans and promote equitable access while helping reduce the burden of gMG. In the first activity of this CME Outfitters BriefCase series, expert faculty will differentiate MOAs, safety considerations, and efficacy data of currently approved FcRn antagonists for the treatment of gMG. Faculty will incorporate strategies to identify patients with gMG who may be appropriate candidates for FcRn antagonist therapy, and apply an individualized approach to treatment planning based on available evidence and patient preferences.

Credit & MOC Details

Credit information is provided by the course provider. We recommend confirming credit eligibility with the provider or your licensing board before starting the activity.

Target Specialties

Faculty 2

All faculty

Gil I Wolfe, MD

State University of New York (SUNY) Distinguished Professor, University at Buffalo Jacobs School of Medicine and Biomedical Sciences

Neurology

2 courses
Neelam Goyal, MD

Clinical Professor, Division of Neuromuscular Medicine, Stanford University Hospital

Neurology

2 courses

Pricing

Free

Reported to ACCME by the provider

On-demand / recorded video
includes Article / monograph / reference
includes Case study / clinical scenario
Credit · Up to 0.5 credits
MOC · Up to 0.5 points
Commercial Support

Released

Jan 30, 2026
Last day to claim credit

Mar 7, 2027 5 months left

Personalizing Therapy in a Complex MuSK+ Patient

Faculty 2

Gil I Wolfe, MD

Neelam Goyal, MD

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