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StatPearls, LLC

  • Diabetic Retinopathy
  • Endocarditis, Subacute Bacterial
  • Hand Strength
  • Immunosuppression Therapy
  • Retinal Hemorrhage

Roth Spots

White-centered retinal hemorrhages, or Roth spots, are retinal hemorrhages distinguished by central pale areas observed on fundoscopic examination. These lesions most commonly occur in the setting of infective endocarditis, particularly subacute bacterial endocarditis, in which prevalence reaches approximately 80%. Additional associations include hematologic disorders such as leukemia and anemia, vascular conditions including hypertensive retinopathy and preeclampsia, and metabolic disorders such as diabetic retinopathy. Risk factors reflect underlying systemic disease, including immunosuppression, coagulopathy, and uncontrolled hypertension or hyperglycemia. Roth spots arise from localized vascular injury, with central fibrin-platelet aggregates or leukocyte collections indicating microvascular ischemia and necrosis. Clinically, these lesions are often asymptomatic but may signal severe systemic illness. Diagnosis relies on careful ophthalmoscopic examination, frequently complemented by systemic evaluation for causative conditions. Management focuses on addressing the underlying disorder, with ophthalmic findings typically resolving following systemic treatment. Complications are uncommon but may reflect severe vascular or hematologic pathology. Prognosis is determined primarily by the underlying systemic disease rather than the retinal lesions themselves. This activity for healthcare professionals is designed to sharpen learners’ skills in evaluating and managing Roth spots. Participants will broaden their grasp of the symptom’s etiologies, risk factors, pathophysiology, clinical presentation, and evidence-based diagnostic and therapeutic strategies. Improved competence will equip clinicians to collaborate with interprofessional teams providing care for affected individuals.

Credit & MOC Details

Credit information is provided by the course provider. We recommend confirming credit eligibility with the provider or your licensing board before starting the activity.

Credit types

AAPA Category 1 Credit™Up to 2 creditsAMA PRA Category 1 Credit™Up to 2 creditsNursingUp to 2 creditsPharmacyUp to 2 credits

MOC types

ABS — Accredited CMEUp to 2 pointsABPATH — Lifelong LearningUp to 2 pointsABTS — Accredited CMEUp to 2 pointsABIM — Medical KnowledgeUp to 2 pointsABS — Self-AssessmentUp to 2 pointsABP — Lifelong Learning and Self-AssessmentUp to 2 pointsABTS — Self-AssessmentUp to 2 points

FDA REMS

No

Qualifies for MIPS

No

Target Specialties

Cross-Specialty

Relevant across 6 specialties.

Pricing

Fee varies

This provider typically $49–98

See fees on statpearls.com

Listed by the provider

  • Article / monograph / reference
  • Credit · Up to 2 credits
  • MOC · Up to 2 points
  • Fee varies · this provider typically $49–98
  • Released
    Sep 1, 2026
  • Last day to claim credit
    Sep 1, 2029 3 years left

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