Drs. Steven Fishbane and Maurizio Gallieni discuss chronic kidney disease-associated pruritus (CKD-aP), a prevalent and under-recognized complication of CKD. They review the epidemiology, pathophysiology, and treatment strategies supported by pivotal phase 3 trials and new European S2k guidelines, including the use of difelikefalin, a kappa-opioid receptor agonist. Additional insights from biomarker analyses in the KALM studies underscore the link between inflammation and pruritus severity, suggesting a dual mechanism of action for difelikefalin. The program emphasizes the importance of actively screening for CKD-aP and using validated tools to assess symptom burden in clinical practice.
Credit & MOC Details
Credit information is provided by the course provider. We recommend confirming credit eligibility with the provider or your licensing board before starting the activity.
Credit types
MOC types
FDA REMS
Qualifies for MIPS
Target Specialties
Pricing
CME included with membership
| Free Registration | Free |
| Tufts-Affiliated HCP - Early Bird (by 10/5/26) | $75 |
| Tufts-Affiliated HCP - Standard | $175 |
| Trainees & Allied Health - Early Bird (by 10/5/26) | $75 |
| Trainees & Allied Health - Standard | $175 |
| Physicians - Early Bird (by 10/5/26) | $150 |
+3 more tiers
Collected from the provider’s public pages · source
Specialties served/covered
- Advanced Heart Failure & Transplant Cardiology
- Allergy & Clinical Immunology
- Cardiovascular Disease
- Communication & Shared Decision-Making
- Dermatology
- Diagnostic Radiology
- Endocrinology, Diabetes & Metabolism
- Family Medicine
- Gastroenterology
- General & Adult Psychiatry
- General Pediatrics
- Gynecologic Oncology
- Head & Neck Surgery
- Hematology
- Maternal-Fetal Medicine
- Medical Genetics & Genomics
- Medical Oncology
- Mood & Anxiety Disorders
- Nephrology
- Neurology
- Neuromuscular Medicine
- Neuroradiology
- Obstetrics & Gynecology
- Ophthalmology
- Pediatric Neurology
- Psychopharmacology
- Psychotic Disorders
- Pulmonary Disease
- Radiation Oncology
- Rheumatology
- Sleep Medicine
- Surgical Oncology
- Transplant Hepatology
- Urological Oncology
- Vascular Neurology
- Cardio-Vascular
- Cross-Specialty
- ENT & Head Neck
- GI & Liver
- Medical Subspecialties
- Neurology
- Ob/Gyn
- Oncology & Hematology
- Pediatrics
- Primary care
- Psychiatry
- Radiology
- Surgery
- Urology
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Pricing
Free
Reported to ACCME by the provider
- Enduring / On-demand
- Credit · Up to 0.25 credits
- Commercial Support
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ReleasedFeb 1, 2026
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Last day to claim creditFeb 2, 2027 4 months left
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