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StatPearls, LLC

  • Multiple Endocrine Neoplasia Type 1
  • Neurofibromatosis 1
  • Somatostatin
  • Somatostatinoma
  • Steatorrhea

Somatostatinoma

Somatostatinoma is a rare, functional neuroendocrine tumor (NET) that primarily arises in the pancreas and duodenum, characterized by excessive production of somatostatin. This hormone inhibits numerous gastrointestinal and endocrine functions. Clinically, this condition often presents with a classic triad of diabetes mellitus, cholelithiasis, and steatorrhea, resulting from hormonal suppression. Although NETs are increasingly diagnosed due to improved imaging techniques, somatostatinomas remain exceedingly rare, accounting for less than 5% of functional pancreatic NETs. These tumors may occur sporadically or in association with hereditary syndromes, eg, multiple endocrine neoplasia type 1, VHL, and neurofibromatosis type 1. An interprofessional team approach is essential for optimal management, including early recognition of potential genetic syndromes and individualized therapy to balance disease control and quality of life. This course explores the complexities surrounding this condition, including the stepwise diagnostic approach involving clinical suspicion, elevated fasting plasma somatostatin levels, imaging studies, and histopathological confirmation via biopsy, as well as treatment, which is guided by tumor location, grade, and stage. This activity is designed for healthcare professionals to enhance their competence in identifying somatostatinomas, performing the recommended evaluation, and implementing an appropriate interprofessional approach when managing this condition.

Credit & MOC Details

Credit information is provided by the course provider. We recommend confirming credit eligibility with the provider or your licensing board before starting the activity.

Credit types

AAPA Category 1 Credit™Up to 1.5 creditsAMA PRA Category 1 Credit™Up to 1.5 creditsNursingUp to 1.5 creditsPharmacyUp to 1.5 credits

MOC types

ABS — Accredited CMEUp to 1.5 pointsABPATH — Lifelong LearningUp to 1.5 pointsABA — Lifelong LearningUp to 1.5 pointsABTS — Accredited CMEUp to 1.5 pointsABIM — Medical KnowledgeUp to 1.5 pointsABS — Self-AssessmentUp to 1.5 pointsABTS — Self-AssessmentUp to 1.5 points

FDA REMS

No

Qualifies for MIPS

No

Target Specialties

Cross-Specialty

Relevant across 9 specialties.

Pricing

Fee varies

This provider typically $49–98

See fees on statpearls.com

Listed by the provider

  • Article / monograph / reference
  • Credit · Up to 1.5 credits
  • MOC · Up to 1.5 points
  • Fee varies · this provider typically $49–98
  • Released
    Sep 1, 2026
  • Last day to claim credit
    Sep 1, 2029 3 years left

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